MEMORIA 2024 - Área 1. Hematología y Oncología Clínico

Área 1. Hematología y Oncología Clínico - Experimental. Genética Clínica

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: se mejoran los datos de 2023 aunque hay un bajón en el liderazgo. Sin embargo lideramos publicaciones de mayor calidad subiendo tanto en factor de impacto medio como en deciles. El liderazgo femenino sigue siendo un aspecto a destacar.
Captación de talento científico: se han conseguido 9 ayudas de recursos humanos competitivas. Además, gracias al aumento de la financiación se ha podido ampliar el personal de apoyo a la investigación que se tenía en 2023.
Dinamizar la captación de recursos: la captación de recursos se mantiende consiguiendo 12 ayudas (1 menos que en 2023) pero con mucha más financiación (multiplicado por cuatro). Los ingresos por estudios de investigación clínica se han incrementado notablemente con respecto a 2023 (24%).

6 Grupos de Investigación

HEMATOLOGÍA Y ONCOLOGÍA MÉDICA CLÍNICO-EXPERIMENTAL (CONSOLIDADO)
CONTROL MOLECULAR DE LA PROLIFERACIÓN Y DIFERENCIACIÓN (CONSOLIDADO)
TERAPIAS MOLECULARES Y BIOMARCADORES DE TUMORES SÓLIDOS (CONSOLIDADO)
INTEGRACIÓN MORFOFUNCIONAL DE CÉLULAS Y TEJIDOS (CONSOLIDADO)
METALOFÁRMACOS ANTITUMORALES NO CONVENCIONALES (CONSOLIDADO)
PATOLOGÍA MOLECULAR Y FARMACOGENÉTICA (CONSOLIDADO)

INDICADORES GENERALES

Nº Publicaciones

696.7

Impacto Total

7.18

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	90 (92.78%)	666.5	7.41
Revisiones	7 (7.22%)	30.2	4.31

70.1

Q1%

30.93

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	64	29	8
Revisiones	4	1	0

INDICADORES DE LIDERAZGO

29 (30.0%)

Nº Publicaciones

169.6

Impacto Total

5.85

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	17 (58.62%)	120.8	7.11
Hombre	12 (41.38%)	48.8	4.07

68.97

Q1%

34.48

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	14	9	1
Hombre	6	1	0

OTROS INDICADORES

18.69

HCP10% (2020-2024)

36.25

HCP10 Liderado% (2020-2024)

23.75

HCP10 Lid. Mujeres% (2020-2024)

1.25

Crown (2020-2024)

57.73

Open Access%

53.61

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Bravo-Perez C, Blanco A, Revilla N, ..., de la Morena-Barrio ME*, ..., Corral J*. Thrombotic risk and features of patients with inferior vena cava agenesis: a multicentre, retrospective, observational study. Lancet Haematology, 2024, 11, e606-e616, PMID: 38878784, FI: 17.7

Garcia-Vazquez FA*, Garrappa G, Luongo C, ..., Jimenez-Movilla M*. Magnetic-Assisted Control of Eggs and Embryos via Zona Pellucida-Linked Nanoparticles. Advanced Science, 2024, 11, e2306901, PMID: 38447155, FI: 14.1

Castejon-Grinan M, Cerdido S, Sanchez-Beltran J, ..., Garcia-Borron JC*. Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage. Redox Biology, 2024, 72, 103135, PMID: 38565069, FI: 11.9

Castejon-Grinan M*, Albers E, Simon-Carrasco L et al. PICH deficiency limits the progression of MYC-induced B-cell lymphoma. Blood Cancer Journal, 2024, 14, 16, PMID: 38253636, FI: 11.6

Cerdido S, Abrisqueta M, Sanchez-Beltran J, ..., Herraiz C*. MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42. Cancer Letters, 2024, 581, 216484, PMID: 38008393, FI: 10.1

LISTADO COMPLETO

Nishio S, Emori C, Wiseman B, ..., Algarra B et al. ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell, 2024, 187, 1440-1459.e24, PMID: 38490181, FI: 42.5

Galanaud JP, Trujillo-Santos J, Bikdeli B et al. Clinical Presentation and Outcomes of Patients With Cancer-Associated Isolated Distal Deep Vein Thrombosis. Journal of Clinical Oncology, 2024, 42, 529-537, PMID: 37471683, FI: 41.9

Mateos MV, Martinez-Lopez J, Rodriguez Otero P, ..., de Arriba F et al. Curative Strategy for High-Risk Smoldering Myeloma: Carfilzomib, Lenalidomide, and Dexamethasone (KRd) Followed by Transplant, KRd Consolidation, and Rd Maintenance. Journal of Clinical Oncology, 2024, 42, 3247-3256, PMID: 39038268, FI: 41.9

Chion A, Byrne C, Atiq F, ..., Aguila S et al. The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. Blood, 2024, 144, 1445-1456, PMID: 38996211, FI: 23.1

Gonzalez-Lopez TJ, Bermejo-Vega N, Cardesa-Cabrera R, ..., Lozano ML et al. Fostamatinib effectiveness and safety for immune thrombocytopenia in clinical practice. Blood, 2024, 144, 646-656, PMID: 38843478, FI: 23.1

Guerrero C, Puig N, Cedena MT, ..., de Arriba F et al. Predictors of unsustained measurable residual disease negativity in transplant-eligible patients with multiple myeloma. Blood, 2024, 143, 597-603, PMID: 38048552, FI: 23.1

Diez-Campelo M, Lopez-Cadenas F, Xicoy B, ..., Amigo ML et al. Low dose lenalidomide versus placebo in non-transfusion dependent patients with low risk, del(5q) myelodysplastic syndromes (SintraREV): a randomised, double-blind, phase 3 trial. Lancet Haematology, 2024, 11, e659-e670, PMID: 39033767, FI: 17.7

Gonzalez-Calle V, Rodriguez-Otero P, Calasanz MJ, ..., de Arriba F et al. High-risk cytogenetic abnormalities in multiple myeloma: PETHEMA-GEM experience. Hemasphere, 2024, 8, e70031, PMID: 39665068, FI: 14.6

Arrizabalaga L, Garcia-Torralba E, Galluzzi L et al. Targeting CDK2 to circumvent treatment resistance in HR(+) breast cancer. Trends in Molecular Medicine, 2024, S1471-4914(24)00342-3 [pii], PMID: 39732571, FI: 13.8

Santaliestra M, Garrote M, Noya MS, ..., Ferrer-Marin F et al. Prognostic value of response to first-line hydroxyurea according to IPSET stratification in essential thrombocythemia. Leukemia, 2024, 38, 2636-2643, PMID: 39333760, FI: 13.4

Bianchi E, Jimenez-Movilla M, Cots-Rodriguez P et al. No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1. Science Advances, 2024, 10, eadk6352, PMID: 38381819, FI: 12.5

Medina-Herrera A, Vazquez I, Cuenca I, ..., De Arriba F et al. The genomic profiling of high-risk smoldering myeloma patients treated with an intensive strategy unveils potential markers of resistance and progression. Blood Cancer Journal, 2024, 14, 74, PMID: 38684670, FI: 11.6

Rey-Bua B, Grande C, Sanchez Blanco JJ et al. Ibrutinib in Combination with R-GemOx in Patients with Relapsed or Refractory Diffuse Large B-cell Lymphoma of Nongerminal Center B-cell-like Type: Phase II Clinical Trial of the Spanish GELTAMO Group. Clinical Cancer Research, 2024, 30, 3704-3714, PMID: 38900037, FI: 10.2

Siddiqui F, Tafur A, Hussain M et al. COLABORADORES: Adarraga MD, Alberich-Conesa A, Aibar J, ... The prognostic value of blood cellular indices in pulmonary embolism. American Journal of Hematology, 2024, 99, 1704-1711, PMID: 38816957, FI: 9.9

Cuenca-Zamora EJ, Guijarro-Carrillo PJ, Lopez-Poveda MJ, ..., Ferrer-Marin F*. miR-146a(-/-) mice model reveals that NF-kappaB inhibition reverts inflammation-driven myelofibrosis-like phenotype. American Journal of Hematology, 2024, 99, 1326-1337, PMID: 38646919, FI: 9.9

Ortega A.G., Jiménez D., Pedro-Tudela A. et al. Age-Related Differences in the Presentation, Management, and Clinical Outcomes of 100,000 Patients With Venous Thromboembolism in the RIETE Registry Archivos de Bronconeumologia, 2024, 60, PMID: null, FI: 9.2

Kinoshita H, Martinez-Ordonez A, Cid-Diaz T, ..., Albaladejo-Gonzalez A et al. Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation. Developmental Cell, 2024, 59, 1972-1987.e8, PMID: 38815584, FI: 8.7

Garcia Molina P, Saura-Sanmartin A, Berna J, ..., Rodriguez Lopez JN et al. Considerations about the inhibition of monophenolase and diphenolase activities of tyrosinase. Characterization of the inhibitor concentration which generates 50 % of inhibition, type and inhibition constants. A review. International Journal of Biological Macromolecules, 2024, 267, 131513, PMID: 38608979, FI: 8.5

Gonzalez-Calle V, Rodriguez-Otero P, Sureda A, De Arriba F et al. Selinexor, daratumumab, bortezomib and dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma: results of the phase II, nonrandomized, multicenter GEM-SELIBORDARA study. Haematologica, 2024, 109, 2219-2228, PMID: 38356463, FI: 7.9

Puig N, Agullo C, Contreras T, ..., De Arriba F et al. Single-point and kinetics of peripheral residual disease by mass spectrometry to predict outcome in patients with high-risk smoldering multiple myeloma included in the GEM-CESAR trial. Haematologica, 2024, 109, 4056-4066, PMID: 38988266, FI: 7.9

Martinez-Cuadron D, Megias-Vericat JE, Gil C, ..., Amigo ML et al. Outcomes after intensive chemotherapy for secondary and myeloid-related changes acute myeloid leukemia patients aged 60 to 75 years old: a retrospective analysis from the PETHEMA registry. Haematologica, 2024, 109, 115-128, PMID: 37199127, FI: 7.9

Alburquerque-Gonzalez B, Montoro-Garcia S, Bernabe-Garcia A, ..., Conesa-Zamora P*. Monastrol suppresses invasion and metastasis in human colorectal cancer cells by targeting fascin independent of kinesin-Eg5 pathway. Biomedicine & Pharmacotherapy, 2024, 175, 116785, PMID: 38781869, FI: 7.5

Cohen O, Waldman Radinsky L, Kenet G et al. Venous thromboembolism characteristics and outcomes among RIETE patients tested and untested for inherited thrombophilia. Blood Advances, 2024, 8, 4950-4959, PMID: 38669351, FI: 7.1

Salas MQ, Cascos E, Lopez-Garcia A, ..., Heras Fernando I et al. Cardiac events after allo-HCT in patients with acute myeloid leukemia. Blood Advances, 2024, 8, 5497-5509, PMID: 39178345, FI: 7.1

Kasparkova J, Hernandez-Garcia A, Kostrhunova H, ..., Ruiz J. Novel 2-(5-Arylthiophen-2-yl)-benzoazole Cyclometalated Iridium(III) dppz Complexes Exhibit Selective Phototoxicity in Cancer Cells by Lysosomal Damage and Oncosis. Journal of Medicinal Chemistry, 2024, 67, 691-708, PMID: 38141031, FI: 6.8

Marco A, Ashoo P, Hernandez-Garcia S, ..., Ruiz J. Novel Re(I) Complexes as Potential Selective Theranostic Agents in Cancer Cells and In Vivo in Caenorhabditis elegans Tumoral Strains. Journal of Medicinal Chemistry, 2024, 67, 7891-7910, PMID: 38451016, FI: 6.8

Contreras-Toledo D, Jimenez-Fonseca P, Lopez CL, ..., Carmona-Bayonas A. Dynamic nature of BRAF or KRAS p.G12C mutations in second-line therapy for advanced colorectal cancer patients: do early and late effects exist? British Journal of Cancer, 2024, 130, 777-787, PMID: 38191609, FI: 6.8

Kasparkova J, Novohradsky V, Ruiz J et al. Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells. Chemico-Biological Interactions, 2024, 392, 110921, PMID: 38382705, FI: 5.4

Salas MQ, Cascos E, Lopez-Garcia A, ..., Heras Fernando I et al. Cardiac events occurring after allogeneic hematopoietic cell transplantation with post-transplant cyclophosphamide. Study conducted on behalf of the GETH-TC. Bone Marrow Transplantation, 2024, 59, 1694-1703, PMID: 39277653, FI: 5.2

Mora E, Montoro J, Balaguer A, ..., Heras I et al. Total body irradiation versus thiotepa/busulfan-based conditioning regimens for myeloablative allogeneic stem cell transplantation in adults with acute lymphoblastic leukemia. Bone Marrow Transplantation, 2024, 59, 1137-1145, PMID: 38755458, FI: 5.2

Labrador J, Martinez-Cuadron D, Boluda B, ..., Amigo ML et al. Evolving patterns and clinical outcome of genetic studies performed at diagnosis in acute myeloid leukemia patients: Real life data from the PETHEMA Registry. Cancer, 2024, 130, 3436-3451, PMID: 38896056, FI: 5.1

Perez-Wert P, Custodio A, Jimenez-Fonseca P, Carmona-Bayonas A et al. Efficacy and safety of chemotherapy in young patients with advanced gastroesophageal adenocarcinoma: data from the Spanish AGAMENON-SEOM registry. Gastric Cancer, 2024, 27, 131-145, PMID: 37964032, FI: 5.1

Gabara C, Aibar J, Nishimoto Y et al. COLABORADORES: Agudo P, Aibar J, Alberich-Conesa A, ... Clinical outcomes after discontinuing anticoagulant therapy in patients with first unprovoked venous thromboembolism. Journal of Thrombosis and Haemostasis, 2024, 22, 2234-2246, PMID: 38762019, FI: 5.0

Fonseca-Santos M, Bailen R, Lopez-Godino O et al. Characterization of Chronic Graft-versus-host Disease After Haploidentical Stem Cell Transplantation With Posttransplant Cyclophosphamide: A Study on Behalf of GETH-TC. Transplantation, 2024, 108, 2134-2143, PMID: 38685204, FI: 5.0

Zamora-Canovas A, de la Morena-Barrio B, Marin-Quilez A, ..., Rivera J*, Lozano ML. Targeted long-read sequencing identifies and characterizes structural variants in cases of inherited platelet disorders. Journal of Thrombosis and Haemostasis, 2024, 22, 851-859, PMID: 38007062, FI: 5.0

Zaninetti C, Rivera J, Vater L et al. Aggregates of nonmuscular myosin IIA in erythrocytes associate with GATA1- and GFI1B-related thrombocytopenia. Journal of Thrombosis and Haemostasis, 2024, 22, 1179-1186, PMID: 38103735, FI: 5.0

Guarnera L, D'Addona M, Bravo-Perez C et al. KMT2A Rearrangements in Leukemias: Molecular Aspects and Therapeutic Perspectives. International Journal of Molecular Sciences, 2024, 25, PMID: 39201709, FI: 4.9

Montenegro M.F., Teruel J.A., García-Molina P., ..., Rodríguez-López J.N. et al. Molecular Docking Studies of Ortho-Substituted Phenols to Tyrosinase Helps Discern If a Molecule Can Be an Enzyme Substrate International Journal of Molecular Sciences, 2024, 25, PMID: null, FI: 4.9

Serna MJ, Rivera-Caravaca JM, Lopez-Galvez R, ..., Roldan V. Dynamic assessment of CHA(2)DS(2)-VASc and HAS-BLED scores for predicting ischemic stroke and major bleeding in atrial fibrillation patients. Revista Espanola de Cardiologia, 2024, 77, 835-842, PMID: 38460882, FI: 4.9

de Arriba de la Fuente F*, Gironella Mesa M, Hernandez Garcia MT et al. Unravelling Transplant-Ineligible Newly Diagnosed Multiple Myeloma Treatment in Real-World Practice in Spain: The CARINAE Study. Pharmaceuticals, 2024, 17, PMID: 39458913, FI: 4.8

Navarro Santana B, Garcia-Torralba E, Viveros-Carreno D et al. Complications of HIPEC for ovarian cancer surgery: evaluation over two time periods. International Journal of Gynecological Cancer, 2024, 34, 1-9, PMID: 37669829, FI: 4.7

Ballester FJ*, Hernandez-Garcia A, Santana MD, ..., Ruiz J. Photoactivatable Ruthenium Complexes Containing Minimal Straining Benzothiazolyl-1,2,3-triazole Chelators for Cancer Treatment. Inorganic Chemistry, 2024, 63, 6202-6216, PMID: 38385171, FI: 4.7

Pinana JL, Tridello G, Xhaard A, ..., Heras I et al. Upper and/or Lower Respiratory Tract Infection Caused by Human Metapneumovirus After Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Infectious Diseases, 2024, 229, 83-94, PMID: 37440459, FI: 4.5

Garcia-Torralba E, Garcia-Lorenzo E, Doger B et al. Immunotherapy in Neuroendocrine Neoplasms: A Diamond to Cut. Cancers, 2024, 16, PMID: 39061170, FI: 4.4

Kwon M, Gomez-Centurion I, Oarbeascoa G, ..., Heras I et al. Real-World Experience with Isavuconazole in Allogeneic Stem Cell Transplantation in Spain. Transplantation and Cellular Therapy, 2024, 30, 1033.e1-1033.e8, PMID: 38871055, FI: 4.4

Ródenas Quiñonero I., Marco-Ayala J., Chen-Liang T.H., ..., Lozano M.L. et al. The Value of Bone Marrow Assessment by FDG PET/CT, Biopsy and Aspirate in the Upfront Evaluation of Mantle Cell Lymphoma: A Nationwide Cohort Study Cancers, 2024, 16, PMID: null, FI: 4.4

Segura-Diaz A, Stuckey R, Florido Y, ..., Ferrer-Marin F et al. DNMT3A/TET2/ASXL1 Mutations are an Age-independent Thrombotic Risk Factor in Polycythemia Vera Patients: An Observational Study. Thrombosis and Haemostasis, 2024, 124, 669-675, PMID: 38190984, FI: 4.3

Bravo-Perez C, Cifuentes-Riquelme R, Padilla J, ..., Corral J. The whole is greater than the sum of its parts: Long-read sequencing for solving clinical problems in haematology. Journal of Cellular and Molecular Medicine, 2024, 28, e17961, PMID: 38260950, FI: 4.2

Trujillo-Santos J, Demelo-Rodriguez P, Bravo de Laguna-Taboada A et al. Optimizing Venous Stenting: Consensus Recommendations for Enhanced Management of Lower Extremity Deep Vein Thrombosis. Seminars in Thrombosis and Hemostasis, 2024, 50, 883-893, PMID: 38733984, FI: 4.1

Brenner B, Tzoran I, Bikdeli B et al. Venous Thromboembolism after Hospital Discharge: Temporal Trends in Baseline Characteristics, Prevention, Treatment, and 90-day Outcomes. Seminars in Thrombosis and Hemostasis, 2024, 51, 301-311, PMID: 39419078, FI: 4.1

Bravo-Perez C, Gurnari C. A tower of babel of acronyms? The shadowlands of MGUS/MBL/CHIP/TCUS. Seminars in Hematology, 2024, 61, 43-50, PMID: 38350765, FI: 4.1

Diaz-Flores L, Gutierrez R, Gonzalez-Gomez M, ..., Madrid JF et al. Phenomena of Intussusceptive Angiogenesis and Intussusceptive Lymphangiogenesis in Blood and Lymphatic Vessel Tumors. Biomedicines, 2024, 12, PMID: 38397861, FI: 3.9

Velasco-Durantez V, Cruz-Castellanos P, Hernandez R, ..., Zafra M et al. Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients. Scientific Reports, 2024, 14, 3188, PMID: 38326426, FI: 3.9

Torres-Esquius S, Beas F, Chen-Liang TH, ..., Lozano ML et al. Germline assessment for alloHSCT candidates over 50 years: A 'Fast-Track' screening in myeloid neoplasms. British Journal of Haematology, 2024, 205, 503-509, PMID: 38639421, FI: 3.8

Soler-Espejo E, Rivera-Caravaca JM, Bru-Canovas JD, ..., Roldan V. Patients with atrial fibrillation and common exclusion criteria from clinical trials are at high risk of clinical events: the Murcia AF Project II (MAFP-II) cohort study. Internal and Emergency Medicine, 2024, 19, 1941-1948, PMID: 38965203, FI: 3.8

Ferrer-Marin F*, Hernandez-Boluda JC, Alvarez-Larran A. Essential thrombocythaemia: A contemporary approach with new drugs on the horizon. British Journal of Haematology, 2024, 204, 1605-1616, PMID: 38586911, FI: 3.8

Berna-Erro A, Granados MP, Teruel-Montoya R et al. SARAF overexpression impairs thrombin-induced Ca(2+) homeostasis in neonatal platelets. British Journal of Haematology, 2024, 204, 988-1004, PMID: 38062782, FI: 3.8

Liu ZJ, Thom C, Nitulescu II, ..., Teruel-Montoya R et al. CDK8/19 inhibition triggers a switch from mitosis to endomitosis in cord blood megakaryocytes. British Journal of Haematology, 2024, 205, 2481-2486, PMID: 39413769, FI: 3.8

Rojo-Carrillo JJ, Garrido-Rodriguez P, Llamas-Lopez M, ..., Corral J. Landscape of antisense genes in the human genome and identification of new human hepatic antisense RNAs by long-read sequencing. Bmc Genomics, 2024, 25, 1148, PMID: 39604851, FI: 3.7

Burgos MA, Rosique L, Piqueras F, ..., Hellin D et al. Reducing variability in nasal surgery outcomes through computational fluid dynamics and advanced 3D virtual surgery techniques. Heliyon, 2024, 10, e26855, PMID: 38463850, FI: 3.6

Piqueras-Sanchez C, Esteve-Pastor MA, Moreno-Fernandez J, ..., Roldan V et al. Advances in the medical treatment and diagnosis of intracranial hemorrhage associated with oral anticoagulation. Expert Review of Neurotherapeutics, 2024, 24, 913-928, PMID: 39039686, FI: 3.4

Pinana JL, Vazquez L, Heras I et al. Omicron SARS-CoV-2 infection management and outcomes in patients with hematologic disease and recipients of cell therapy. Frontiers in Oncology, 2024, 14, 1389345, PMID: 39015498, FI: 3.3

Vicente AI, Luna I, Ruiz JC, ..., Ortuno FJ et al. WHO/ICC Classification for Myelodysplastic Neoplasms/Syndromes Performs Better for Subtype Cytomorphological Diagnosis? Diagnostics, 2024, 14, PMID: 39125507, FI: 3.3

Klajmon A, Natorska J, Corral J et al. Reduced Plasma Selenoprotein P Is Associated With Type I Antithrombin Deficiency and a Prothrombotic State. Archives of Pathology & Laboratory Medicine, 2024, 10.5858/arpa.2024-0162-OA [doi], PMID: 39265995, FI: 3.2

García de Guadiana-Romualdo L., Botella L.A., Rodríguez Rojas C., ..., Conesa Zamora P. et al. Mortality prediction model from combined serial lactate, procalcitonin and calprotectin levels in critically ill patients with sepsis: A retrospective study according to Sepsis-3 definition Medicina Intensiva, 2024, 48, PMID: null, FI: 3.1

Fernandez-Suarez E, Gonzalez-Del Pozo M, Mendez-Vidal C, ..., de la Morena-Barrio B et al. Long-read sequencing improves the genetic diagnosis of retinitis pigmentosa by identifying an Alu retrotransposon insertion in the EYS gene. Mobile dna, 2024, 15, 9, PMID: 38704576, FI: 3.1

Martinez-Janez N, Ezquerra MB, Manso Sanchez LM, ..., de la Pena FA et al. First-line therapy with palbociclib in patients with advanced HR(+)/HER2(-) breast cancer: The real-life study PALBOSPAIN. Breast Cancer Research and Treatment, 2024, 206, 317-328, PMID: 38561577, FI: 3.0

Garcia-Torralba E, Perez Ramos M, Ivars Rubio A, ..., Ayala de la Pena F*. Deconstructing neutrophil to lymphocyte ratio (NLR) in early breast cancer: lack of prognostic utility and biological correlates across tumor subtypes. Breast Cancer Research and Treatment, 2024, 205, 475-485, PMID: 38453782, FI: 3.0

Aguila S*, Gonzalez-Conejero R*, Martinez C*. microRNAs and thrombo-inflammation: relationship in sight. Current Opinion in Hematology, 2024, 31, 140-147, PMID: 38277182, FI: 2.9

Marce S, Mendez A, Xicoy B, ..., Ferrer-Marin F et al. e14a2 Transcript Favors Treatment-Free Remission in Chronic Myeloid Leukemia When Associated with Longer Treatment with Tyrosine Kinase Inhibitors and Sustained Deep Molecular Response. Journal of Clinical Medicine, 2024, 13, PMID: 38337473, FI: 2.9

Mingot-Castellano ME, Reguera-Ortega JL, Zafra Torres D, ..., Lopez-Godino O et al. Use of Eltrombopag to Improve Thrombocytopenia and Tranfusion Requirement in Anti-CD19 CAR-T Cell-Treated Patients. Journal of Clinical Medicine, 2024, 13, PMID: 39274330, FI: 2.9

Mihic-Gongora L, Jimenez-Fonseca P, Coca-Membribes S, ..., Carmona-Bayonas A et al. Physical Activity in Patients with Advanced Cancer: Sociodemographic, Clinical, and Psychological Correlates. Brain Sciences, 2024, 14, PMID: 38928572, FI: 2.8

Paredero-Perez I, Jimenez-Fonseca P, Cano JM, ..., Carmona-Bayonas A et al. State of the scientific evidence and recommendations for the management of older patients with gastric cancer. Journal of Geriatric Oncology, 2024, 15, 101657, PMID: 37957106, FI: 2.7

Garrido-Rodriguez P, Carmena-Bargueno M, de la Morena-Barrio ME, ..., Corral J. Analysis of AlphaFold and molecular dynamics structure predictions of mutations in serpins. Plos one, 2024, 19, e0304451, PMID: 38968282, FI: 2.6

Boyano MD, Asumendi A, Garcia-Borron JC et al. IPCC2023: Looking for translational opportunities by persevering in basic pigment cell research. Pigment Cell & Melanoma Research, 2024, 37, 546-554, PMID: 37917143, FI: 2.6

Sanguansook P, Rodprasert W, Sawangmake C, Gimeno L et al. Expression of IZUMO1 and JUNO in the gonads of domestic cats (Felis catus). Theriogenology, 2024, 220, 70-76, PMID: 38484673, FI: 2.5

Munoz Martin A, Trujillo-Santos AJ, Marti E et al. Improvement of thrombosis management in patients with cancer: a practical consensus document of recommendations for cancer-associated thrombosis patients' healthcare in Spain. Clinical & Translational Oncology, 2024, 26, 1319-1328, PMID: 38349577, FI: 2.5

Arias-Martinez A, Martinez de Castro E, Gallego J, ..., Carmona-Bayonas A et al. Is there a preferred platinum and fluoropyrimidine regimen for advanced HER2-negative esophagogastric adenocarcinoma? Insights from 1293 patients in AGAMENON-SEOM registry. Clinical & Translational Oncology, 2024, 26, 1674-1686, PMID: 38361134, FI: 2.5

Pacheco-Barcia V, Custodio-Cabello S, Carrasco-Valero F, ..., Carmona-Bayonas A et al. Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial. World Journal of Gastrointestinal Oncology, 2024, 16, 386-397, PMID: 38425396, FI: 2.5

Sanchez Canovas M, Garcia Torralba E, Blaya Boluda N, ..., Ayala de la Pena F. Thrombosis and infections associated with PICC in onco-hematological patients, what is their relevance? Clinical & Translational Oncology, 2024, 26, 3226-3235, PMID: 38865035, FI: 2.5

Rivera F, Longo F, Martin Richard M, ..., Carmona A et al. SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of gastric cancer (2023). Clinical & Translational Oncology, 2024, 26, 2826-2840, PMID: 39023829, FI: 2.5

Marco-Ayala J, Asensi Canto P, Suarez M et al. Single-Unit Transfusion Policy in Autologous Hematopoietic Stem Cell Transplantation: Less is Not Worse. Transfusion Medicine Reviews, 2024, 38, 150859, PMID: 39383656, FI: 2.5

Suarez EU, Boluda B, Lavilla E, ..., Amigo ML et al. Do NPM1 and FLT3-ITD mutations modify prognosis in patients treated with non-intensive regimens? Annals of Hematology, 2024, 103, 2845-2851, PMID: 38884787, FI: 2.4

Lakhwani S, Mateos MV, Martinez-Lopez J, ..., De Arriba F et al. Immunoparesis recovery in newly diagnosed transplant ineligible multiple myeloma patients, an independent prognostic factor that complements minimal residual disease. Annals of Hematology, 2024, 103, 5651-5661, PMID: 39438321, FI: 2.4

Garrote M, Lopez-Guerra M, Garcia-Pagan JC, ..., Ferrer-Marin F et al. Genomic classification and outcomes of young patients with polycythemia vera and essential thrombocythemia according to the presence of splanchnic vein thrombosis and its chronology. Annals of Hematology, 2024, 103, 737-747, PMID: 38263537, FI: 2.4

Kiladjian JJ, Marin FF, Al-Ali HK et al. ROP-ET: a prospective phase III trial investigating the efficacy and safety of ropeginterferon alfa-2b in essential thrombocythemia patients with limited treatment options. Annals of Hematology, 2024, 103, 2299-2310, PMID: 38438627, FI: 2.4

Cara-Esteban M, Marin MP, Martinez-Alonso E*, ..., Martinez-Menarguez JA* et al. The Golgi complex of dopaminergic enteric neurons is fragmented in a hemiparkinsonian rat model. Microscopy Research and Technique, 2024, 87, 373-386, PMID: 37855309, FI: 2.1

Diaz-Flores L, Gutierrez R, Garcia-Suarez MP, ..., Madrid JF et al. "Vascular tuft sign" in neuroendocrine tumors of the pancreas. Histology and Histopathology, 2024, 39, 1457-1472, PMID: 39026502, FI: 2.0

Calleja JL, Delgado Sanchez O, Fuentes Pradera MA, ..., Lozano ML et al. Recommendations for the future management of thrombocytopenia in patients with liver cirrhosis: A modified RAND/UCLA appropriateness method. Gastroenterologia y Hepatologia, 2024, 47, 32-50, PMID: 37028757, FI: 1.9

Cruz-Castellanos P, Gil-Raga M, Jimenez-Fonseca P, ..., Garcia-Torralba E et al. Uncertainty and hope in relation to anxiety and depression in advanced lung cancer. Bmj Supportive & Palliative Care, 2024, 13, e847-e850, PMID: 36100428, FI: 1.8

Fernandez Reina A, Lopez Abellan MD, Attaibi Hadri S et al. Reliability of a point of care testing blood gas analyzer for measurement of lactate levels in cerebrospinal fluid. Scandinavian Journal of Clinical & Laboratory Investigation, 2024, 84, 76-78, PMID: 38376201, FI: 1.4

Diaz Lopez MI, Crespo Alvarez E, Martinez Manzano A et al. Usefulness of extended inflammatory parameters related to neutrophil activation reported by Sysmex XN-1000 hematology analyzer for predicting complicated acute appendicitis. Comparison with canonical inflammatory laboratory tests. Cirugia Espanola, 2024, 102, 300-306, PMID: 38342139, FI: 1.3

AYUDAS CONCEDIDAS EN 2024

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

4.75M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.74M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.0M €

Financiación Europea

Nº Ayudas Nacionales

3.72M €

Financiación Nacional

Nº Ayudas Regionales

0.28M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.0M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

22.63K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2024

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2024

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2024

125

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2024

0.67M €

Facturado

Nº Tesis (5 con mención internacional)