MEMORIA 2024 - Área 7. Biotecnología. Aplicaciones Sanitarias de Biociencias

Área 7. Biotecnología. Aplicaciones Sanitarias de Biociencias

OBJETIVOS CIENTÍFICOS VINCULADOS AL PLAN ESTRATÉGICO

Generar conocimiento científico de excelencia: se mantienen los indicadores del año pasado. Buenos indicadores de liderazgo (67%) y de Q1 por encima del 60%.
Captación de talento científico: se ha conseguido una nueva ayuda de recursos humanos competitiva. El número de investigadores se ha podido mantener constante.
Dinamizar la captación de recursos: la captación de recursos se ha mantenido con respecto a años anteriores. Han conseguido ingresos por investigación clínica en consonancia con los años previos.

11 Grupos de Investigación

BIOLOGÍA DE LA REPRODUCCIÓN (CONSOLIDADO)
BIOMEMBRANAS Y SEÑALIZACIÓN CELULAR (CONSOLIDADO)
BIOQUIMICA Y BIOTECNOLOGIA ENZIMATICA (CONSOLIDADO)
FISIOLOGÍA REPRODUCTIVA Y REPRODUCCIÓN ASISTIDA (CONSOLIDADO)
BIOLOGÍA MOLECULAR DE SISTEMAS (CONSOLIDADO)
INVESTIGACIÓN EN GINECOLOGÍA, REPRODUCCIÓN Y MEDICINA MATERNO-FETAL (CONSOLIDADO)
TECNOLOGÍAS DE MODELADO, PROCESAMIENTO Y GESTIÓN DEL CONOCIMIENTO (CONSOLIDADO)
GRUPO DE INVESTIGACIÓN EN RADIOLOGÍA (EMERGENTE)
GRUPO DE RADIOFARMACIA (CLÍNICO ASOCIADO)
GRUPO DE INVESTIGACIÓN EN FÍSICA MÉDICA (EMERGENTE)
FARMACOCINETICA CLINICA Y FARMACOTERAPIA APLICADA (CLÍNICO ASOCIADO)

INDICADORES GENERALES

Nº Publicaciones

182.8

Impacto Total

3.58

Impacto Medio

Tipo	Nº Pubs	FI total	FI Medio
Originales	49 (96.08%)	176.8	3.61
Revisiones	2 (3.92%)	6.0	3.0

64.71

Q1%

11.76

D1%

FI >= 15

Tipo	Nº Q1	Nº D1	Nº FI >= 15
Originales	31	5	0
Revisiones	2	1	0

INDICADORES DE LIDERAZGO

34 (67.0%)

Nº Publicaciones

108.6

Impacto Total

3.19

Impacto Medio

	Nº Pubs	FI total	FI Medio
Mujer	13 (38.24%)	37.7	2.9
Hombre	21 (61.76%)	70.9	3.38

55.88

Q1%

8.82

D1%

FI >= 15

	Nº Q1	Nº D1	Nº FI >= 15
Mujer	7	0	0
Hombre	12	3	0

OTROS INDICADORES

10.96

HCP10% (2020-2024)

78.79

HCP10 Liderado% (2020-2024)

48.48

HCP10 Lid. Mujeres% (2020-2024)

0.95

Crown (2020-2024)

68.63

Open Access%

33.33

Col. International%

* Se muestran las 5 especies, los 10 genes y las 20 enfermedades más nombradas. Los valores están normalizados logarítmicamente en base al número de publicaciones.

INDICADORES EVOLUTIVOS

DESTACADAS

Mulero-Hernandez J, Mironov V, Minarro-Gimenez JA*, ..., Fernandez-Breis JT*. Integration of chromosome locations and functional aspects of enhancers and topologically associating domains in knowledge graphs enables versatile queries about gene regulation. Nucleic Acids Research, 2024, 52, e69, PMID: 38967009, FI: 13.1

Fernández E.I., Jara Valera A.J., Fernández Breis J.T.*. Embedded machine learning of IoT streams to promote early detection of unsafe environments Internet of Things, 2024, 25, PMID: null, FI: 7.6

Martinez-Diaz P, Parra A, Sanchez-Lopez CM, ..., Roca J*, Barranco I*. Small and Large Extracellular Vesicles of Porcine Seminal Plasma Differ in Lipid Profile. International Journal of Molecular Sciences, 2024, 25, PMID: 39000599, FI: 4.9

Abad-Navarro F*, Martinez-Costa C*. A knowledge graph-based data harmonization framework for secondary data reuse. Computer Methods and Programs in Biomedicine, 2024, 243, 107918, PMID: 37981455, FI: 4.8

Lozano-Terol G, Chiozzi RZ, Gallego-Jara J, ..., de Diego Puente T. Relative impact of three growth conditions on the Escherichia coli protein acetylome. Iscience, 2024, 27, 109017, PMID: 38333705, FI: 4.1

LISTADO COMPLETO

Alcorlo M, Luque-Ortega JR, Gago F, Ortega A et al. Flexible structural arrangement and DNA-binding properties of protein p6 from Bacillus subtillis phage phi29. Nucleic Acids Research, 2024, 52, 2045-2065, PMID: 38281216, FI: 13.1

Wettstadt S, Marcos-Torres FJ, Otero-Asman JR, ..., Ortega A et al. Bacterial TonB-dependent transducers interact with the anti-sigma factor in absence of the inducing signal protecting it from proteolysis. Plos Biology, 2024, 22, e3002920, PMID: 39621812, FI: 7.2

Catalan J, Yanez-Ortiz I, Torres-Garrido M, ..., Barranco I et al. Impact of Seminal Plasma Antioxidants on DNA Fragmentation and Lipid Peroxidation of Frozen-Thawed Horse Sperm. Antioxidants, 2024, 13, PMID: 38539855, FI: 6.6

Perez-Lloret M, Reidy E, Lozano-Perez AA et al. Auranofin loaded silk fibroin nanoparticles for colorectal cancer treatment. Drug Delivery and Translational Research, 2024, 10.1007/s13346-024-01719-2 [doi], PMID: 39382824, FI: 5.5

Chacon E, Boria F, Lyer RR et al. COLABORADORES: Darin C, Agnieszka R, Miralpeix E, ... SENECA study: staging endometrial cancer based on molecular classification. International Journal of Gynecological Cancer, 2024, 34, 1313-1321, PMID: 39153831, FI: 4.7

Azcona L, Heras M, Arencibia O et al. Prognostic factors in young women with epithelial ovarian cancer: the Young Ovarian Cancer-Care (YOC-Care) study. International Journal of Gynecological Cancer, 2024, 34, 285-292, PMID: 38086566, FI: 4.7

Illueca Fernandez E., Martinez I.C., Breis J.T.F. et al. Design and Evaluation of a Dryer System for IoT Hyperlocal Particulate Matter Monitoring Device Ieee Sensors Journal, 2024, 24, PMID: null, FI: 4.5

Iniesta Navalon C, Rios-Saorin M, Rentero-Redondo L et al. Impact of ustekinumab exposure on clinical outcomes during induction in inflammatory bowel disease. Revista Espanola de Enfermedades Digestivas, 2024, 10.17235/reed.2024.10521/2024 [doi], PMID: 39629805, FI: 4.0

Parra A, Barranco I, Martinez-Diaz P, ..., Roca J*. Cryogenic electron microscopy reveals morphologically distinct subtypes of extracellular vesicles among porcine ejaculate fractions. Scientific Reports, 2024, 14, 16175, PMID: 39003421, FI: 3.9

Barranco I*, Alminana C, Parra A, ..., Roca J*. RNA profiles differ between small and large extracellular vesicle subsets isolated from porcine seminal plasma. Bmc Genomics, 2024, 25, 1250, PMID: 39731016, FI: 3.7

Fernandez E.I., Valera A.J.J., Breis J.T.F.*. Improving Air Quality Zoning Through Deep Learning and Hyperlocal Measurements Ieee Access, 2024, 12, PMID: null, FI: 3.6

Moreira S, Martins AD, Alves MG, Pastor LM et al. Aminocarb Exposure Induces Cytotoxicity and Endoplasmic Reticulum Stress-Mediated Apoptosis in Mouse Sustentacular Sertoli Cells: Implications for Male Infertility and Environmental Health. Biology-Basel, 2024, 13, PMID: 39336148, FI: 3.5

Abdoune R., Lazib L., Dahmani-Bouarab F., Fernández-Breis J.T.*. ONTO-TDM domain ontology population for a specific discipline Applied Ontology, 2024, 19, PMID: null, FI: 3.5

Gonzalez-Lopez A*. Effect of the oblique incidence of radiation beams on emerging radiation behind lead and concrete shields: a multilayer method for dose transmission calculations. Physics in Medicine and Biology, 2024, 69, PMID: 39626618, FI: 3.4

Lorenzo-Rebenaque L., Muñoz-Baquero M., Diretto G., ..., García-Vázquez F.A. et al. Metabolomic profiling of blood and seminal plasma in the small-spotted catshark (Scyliorhinus canicula): A comparative study of aquarium and wild populations in the Valencia region Global Ecology and Conservation, 2024, 52, PMID: null, FI: 3.4

Parrilla I, Cambra JM, Cuello C, ..., Gil MA*, Martinez EA. Cryopreservation of highly extended pig spermatozoa remodels its proteome and counteracts polyspermic fertilization in vitro. Andrology, 2024, 12, 1356-1372, PMID: 38131448, FI: 3.4

Garcia-Vazquez FA*. Artificial intelligence and porcine breeding. Animal Reproduction Science, 2024, 269, 107538, PMID: 38926001, FI: 3.3

Heras M, Alonso-Espias M, Arencibia O et al. Real Implication of Fertility-Sparing Surgery for Ovarian Cancer: Reproductive Outcomes. Diagnostics, 2024, 14, PMID: 39001314, FI: 3.3

Diaz-Castro J, Toledano JM, Sanchez-Romero J, ..., De Paco Matallana C et al. COVID-19 and Pregnancy: A Dangerous Mix for Bone Turnover and Metabolism Biomarkers in Placenta and Colostrum. Journal of Clinical Medicine, 2024, 13, PMID: 38610889, FI: 2.9

Lago V, Albert MM, Cruz MA, Guijarro-Campillo RA et al. A restrictive stoma policy after colorectal anastomosis in ovarian cancer based on ghost ileostomy use. Ejso, 2024, 50, 108325, PMID: 38636248, FI: 2.9

Martinez-Diaz P, Parra A, Montesdeoca M, ..., Roca J*. Updating Research on Extracellular Vesicles of the Male Reproductive Tract in Farm Animals: A Systematic Review. Animals, 2024, 14, PMID: 39518859, FI: 2.7

Crespo S., Gadea J.*. Use of a Vaginally Administered Gel Containing the GnRH Agonist Triptorelin and a Single, Fixed-Time Artificial Insemination in Pigs under Commercial Conditions: Productive and Economic Impacts Animals, 2024, 14, PMID: null, FI: 2.7

Muñoz-Baquero M., Lorenzo-Rebenaque L., García-Domínguez X., ..., García-Vázquez F.A. et al. Proteomic Insights into Seminal Plasma and Spermatozoa Proteins of Small-Spotted Catsharks, Scyliorhinus canicula: Implications for Reproductive Conservation in Aquariums Animals, 2024, 14, PMID: null, FI: 2.7

Simoncini T, Panattoni A, Cadenbach-Blome T et al. Role of lateral suspension for the treatment of pelvic organ prolapse: a Delphi survey of expert panel. Surgical Endoscopy and Other Interventional Techniques, 2024, 38, 4344-4352, PMID: 38877319, FI: 2.7

Barranco I*, Spinaci M, Nesci S, ..., Roca J*. Seminal extracellular vesicles alter porcine in vitro fertilization outcome by modulating sperm metabolism. Theriogenology, 2024, 219, 167-179, PMID: 38437767, FI: 2.5

Canovas S*, Heras S, Romero-Aguirregomezcorta J* et al. Metabolic profile and glycemic response in fully-grown sows born using assisted reproductive technologies. Theriogenology, 2024, 230, 314-321, PMID: 39368453, FI: 2.5

Pineiro-Silva C, Gadea J*. Optimization of lipofection protocols for CRISPR/Cas9 delivery in porcine zona pellucida intact oocytes: A study of coincubation duration and reagent efficacy. Theriogenology, 2024, 230, 121-129, PMID: 39293174, FI: 2.5

Garcia C, Prieto MT, Escudero F, ..., De Paco Matallana C. The impact of early versus delayed cord clamping on hematological and cardiovascular changes in preterm newborns between 24 and 34 weeks' gestation: a randomized clinical trial. Archives of Gynecology and Obstetrics, 2024, 309, 2483-2490, PMID: 37436461, FI: 2.5

Garriga F, Martinez-Hernandez J, Gener-Velasco N et al. Voltage-dependent anion channels are involved in the maintenance of pig sperm quality during liquid preservation. Theriogenology, 2024, 224, 26-33, PMID: 38723471, FI: 2.5

Pineiro-Silva C, Gadea J*. Optimizing oocyte electroporation for genetic modification of porcine embryos: Evaluation of the parthenogenetic activation. Theriogenology, 2024, 218, 126-136, PMID: 38325149, FI: 2.5

Navarro-Serna S, Pineiro-Silva C, Fernandez-Martin I, ..., Gadea J*. Oocyte electroporation prior to in vitro fertilization is an efficient method to generate single, double, and multiple knockout porcine embryos of interest in biomedicine and animal production. Theriogenology, 2024, 218, 111-118, PMID: 38320372, FI: 2.5

Toledo-Guardiola SM, Parraga-Ros E, Seva J, ..., Matas C*. Artificial insemination of all ejaculated sperm fractions accelerates embryo development and increases the uterine vascularity in the pig. Theriogenology, 2024, 219, 32-38, PMID: 38382215, FI: 2.5

Sanchez-Romero J, Ruiz-Boluda I, Juan-Perez A, ..., Nieto-Diaz A*. Interval between balloon removal and oxytocin administration in cervical ripening with double-balloon in singleton pregnancies: An observational study. International Journal of Gynecology & Obstetrics, 2024, 165, 778-785, PMID: 38009593, FI: 2.4

Sanchez-Romero J, Gallego-Pozuelo RM, Dahmouni-Dahmouni H, ..., de Paco K*. External cephalic version following prior cesarean delivery: A comparative cohort analysis. International Journal of Gynecology & Obstetrics, 2024, 167, 1066-1074, PMID: 38881234, FI: 2.4

Davila Ruiz BJ, Dahlen CR, McCarthy KL, ..., Canovas S et al. Influence of Maternal Supplementation with Vitamins, Minerals, and (or) Protein/Energy on Placental Development and Angiogenic Factors in Beef Heifers during Pregnancy. Veterinary Sciences, 2024, 11, PMID: 38535845, FI: 2.3

Toledo-Guardiola SM, Martinez-Diaz P, Martinez-Nunez R, ..., Soriano-Ubeda C et al. Sperm functionality is differentially regulated by porcine oviductal extracellular vesicles from the distinct phases of the estrous cycle. Reproduction Fertility and Development, 2024, 36, PMID: 38713808, FI: 2.1

Cortes-Sandoval S, Seco-Rovira V*, Beltran-Frutos E, ..., Pastor LM*. Heterogeneity of mesenchymal cells in human amniotic membrane at term. Histology and Histopathology, 2024, 39, 573-593, PMID: 37721417, FI: 2.0

Seco-Rovira V*, Serrano-Sanchez MI*, Beltran-Frutos E*, ..., Pastor LM*. HSP47 expression in the hamster Sertoli cell: An immunohistochemical study. Histology and Histopathology, 2024, 39, 1295-1302, PMID: 38567534, FI: 2.0

Guijarro-Campillo AR, Padilla-Iserte P, Couso B, ..., Nuñez-Sanchez MA et al. Accuracy of ICG compared with technetium-99 m for sentinel lymph node biopsy in vulvar cancer. European Journal of Obstetrics & Gynecology and Reproductive Biology, 2024, 294, 11-19, PMID: 38183845, FI: 1.9

Iniesta-Navalon C, Rios-Saorin M, Rentero-Redondo L et al. Comparative evaluation of point of care assay with ELISA techniques for quantifying serum concentrations of ustekinumab in inflammatory bowel disease patients. Gastroenterologia y Hepatologia, 2024, S0210-5705(24)00284-X [pii], PMID: 39442691, FI: 1.9

Serrano Diaz L, Iniesta Navalon C, Gomez Espin R, ..., Bernal Morell E et al. Comparative effectiveness and drug survival of biosimilar infliximab CPT-13 vs. reference infliximab in inflammatory bowel disease: A retrospective cohort study. Gastroenterologia y Hepatologia, 2024, 47, 553-561, PMID: 37597745, FI: 1.9

Sanguansook P, Martinez-Lopez C, Izquierdo-Rico MJ, ..., Garcia-Vazquez FA*. Development of decellularization protocols for female cat reproductive organs. Research in Veterinary Science, 2024, 173, 105257, PMID: 38636324, FI: 1.8

Garrappa G, Martinez-Lopez C, Jimenez-Movilla M, Garcia-Vazquez FA*. In vitro exposure of porcine sperm to functionalized superparamagnetic nanoparticles. Reproduction in Domestic Animals, 2024, 59 Suppl 3, e14654, PMID: 39396860, FI: 1.7

Ruiz Pelaez E, Hurtado Algar EM, Martinez la Torre T, ..., Hernandez-Caravaca I*. Impact of the COVID-19 lockdown on the O'Sullivan test and gestational diabetes mellitus diagnosis in pregnant Spanish women. Atencion Primaria, 2024, 56, 103006, PMID: 38889596, FI: 1.6

Anez-Castano R, Iniesta-Navalon C, Almanchel-Rivadeneyra M et al. Therapeutic drug monitoring of inhaled tobramycin in a patient with chronic kidney disease. European Journal of Hospital Pharmacy, 2024, ejhpharm-2023-004075 [pii], PMID: 39181698, FI: 1.5

Hernandez-Garcia S, Guerrero-Rubio MA, Henarejos-Escudero P, ..., Gandia-Herrero F*. Exploring in the classroom the relationship between alcohol intake and behavioral disorders through an animal model. Biochemistry and Molecular Biology Education, 2024, 52, 474-479, PMID: 38501696, FI: 0.9

AYUDAS CONCEDIDAS EN 2024

TOTAL DE AYUDAS CONCEDIDAS

Nº Ayudas

0.44M €

Financiación

TOTAL DE AYUDAS RECURSOS HUMANOS CONCEDIDAS

Nº Ayudas

0.06M €

Financiación

TOTAL DE AYUDAS PROYECTOS I+D+i CONCEDIDAS

Nº Ayudas Europeas

0.0M €

Financiación Europea

Nº Ayudas Nacionales

0.25M €

Financiación Nacional

Nº Ayudas Regionales

0.13M €

Financiación Regional

TOTAL DE REDES CONCEDIDAS

Nº Ayudas

0.0M €

Financiación

OTRAS AYUDAS COMPETITIVAS CONCEDIDAS (MOVILIDAD, ORGANIZACIÓN DE EVENTOS CIENTÍFICOS, ...)

Nº Ayudas

0.0K €

Financiación

PROYECTOS DE I+D+i Y AYUDAS DE RRHH ACTIVAS EN 2024

TOTAL AYUDAS

RECURSOS HUMANOS

REDES

PROYECTOS INTERNACIONALES

PROYECTOS NACIONALES

PROYECTOS REGIONALES

INICIADA EN 2024

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

ACTIVOS EN 2024

Nº Estudios

Nº Ensayos Clínicos

Nº Producto Sanitario

Nº Estudios Post-Autorización

Nº Otros Estudios

FACTURACIÓN EN 2024

0.05M €

Facturado

Nº Tesis (0 con mención internacional)